Set several years after the end of Risen, raging titans have devastated the world and pushed humanity to the brink of existence. Subsequently, monstrous creatures have risen from the watery depths of the sea and their attacks have brought all seafaring to a grinding halt.

Em um mundo de fantasia encharcado de piratas de ilhas tropicais, magia vodu e deuses antigos, Titãs colossais surgiram para devastar a terra, e um monstruoso Kraken sob o comando da deusa do mar Mara afunda qualquer navio que ouse o oceano, deixando os últimos remanescentes da Inquisição sitiados na fortaleza of Caldera. A former Inquisition agent is sent undercover among the pirates to uncover a rumored weapon capable of killing the Titans and their beasts. Teaming up with the fierce pirate Patty, who is chasing her legendary father and his hidden treasure, the hero sets sail across the islands in search of the means to strike back against the Titans and free the seas.